Polynucleotides vs. Profhilo: Which is Right for You?

When it comes to rejuvenating your skin and combating signs of ageing, there are many treatments available. Two popular options that both affect layer 2 are Polynucleotides and Profhilo. But how do they differ? Should you choose one over the other—or perhaps use both in tandem? Let’s break it down and compare these two treatments to help you decide which one works best for you.
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Dr Louise Smyth

What are Polynucleotides?

Polynucleotides are naturally occurring molecules that are essential for cellular repair and regeneration. They consist of chains of nucleotides, the building blocks of DNA and RNA. When applied to the skin via injection, they work to boost collagen and elastin production, promote skin hydration, and stimulate tissue repair. Polynucleotides are highly effective for people who have dull, tired-looking skin, as they can help restore vitality and radiance. We love them for the lower face for structural support for lines from the corner of the eyes all the way down to the mouth

How Do Polynucleotides Work?

When injected into the skin, Polynucleotides promote cell regeneration and increase the production of collagen and elastin fibres, which are key to maintaining strong, firm skin. These molecules also help to improve hydration levels in the skin by stimulating the synthesis of hyaluronic acid, which holds moisture in the skin. Polynucleotides improve skin elasticity, reduce pigmentation, and enhance the skin’s overall texture.

What is Profhilo?

Profhilo is a unique injectable skin treatment that involves a high concentration of hyaluronic acid. While most dermal fillers use hyaluronic acid to add volume to areas of the face, Profhilo works differently. Profhilo is not a Filler. It’s designed to provide deep hydration, and as a secondary affect it also improves skin quality by stimulating the production of collagen and elastin in the dermis. Instead of adding volume, Profhilo works to lift, hydrate and tighten the skin, smooth out fine lines, and restore youthful radiance.

How Does Profhilo Work?

Profhilo is made up of a stabilized form of hyaluronic acid with a unique formulation that allows it to spread evenly throughout the skin. When injected, it deeply hydrates and stimulates the fibroblasts (the cells responsible for producing collagen and elastin) to create a firming and tightening effect. Profhilo doesn’t add volume but instead enhances the skin’s overall quality. The result is smoother, more youthful-looking skin that feels plump and hydrated. Profhilo is perfect for people who are looking to tackle mild to moderate signs of ageing, especially in areas that need deep hydration.

Why Do Polynucleotides and Profhilo Work?

Both treatments rely on the body’s natural processes to repair and rejuvenate skin. Polynucleotides stimulate the skin’s regeneration by enhancing cellular activity, encouraging the production of collagen, and improving hydration. They work on a cellular level to restore the skin’s natural resilience and appearance.
On the other hand, Profhilo’s primary mechanism is deep hydration. Hyaluronic acid is known for its ability to bind water molecules, and in Profhilo, it works to restore moisture levels in the skin.

Why Should You Choose One vs. The Other?

Choosing between Polynucleotides and Profhilo depends on your specific skin concerns and your aesthetic goals. Here’s a comparison of when to choose one treatment over the other:

Polynucleotides are best if:
o You have dehydrated or tired-looking skin with signs of ageing
o You want to target skin texture, tone, and radiance.
o You are concerned with fine lines and wrinkles.
o You prefer a natural and holistic approach to rejuvenation.
o You want to encourage the repair of damaged skin cells.
o You are priming the skin before a procedure like Microneedling or Morpheus 8 to get a more amplified result
Profhilo is best if:
o You have mild to moderate skin laxity or sagging.
o You have dry, dehydrated, crepey skin
o You need deep hydration and plumping effects.
o You want to improve the overall skin quality and texture without adding volume.
o You’re looking for mild skin tightening benefits

Can You Combine Polynucleotides and Profhilo?

Yes, in many cases, combining both treatments can yield exceptional results. If you’re dealing with a combination of skin concerns—like skin laxity, dullness, fine lines, and dehydration—combining Polynucleotides and Profhilo can work synergistically.

• Polynucleotides can improve the texture and radiance of the skin, while Profhilo can provide the necessary lifting, tightening, and deep hydration.

• Together, they can stimulate collagen and elastin production from different angles, improving both the internal health of the skin and its outward appearance.
A customised treatment plan incorporating both might be the best option for those, with a certain skin type and face shape, looking for comprehensive skin rejuvenation.

Ultimately, the decision to choose Polynucleotides or Profhilo depends on your skin’s needs and what you aim to achieve with treatment. Both offer unique benefits: Polynucleotides focus on cellular repair, radiance, and texture improvement, while Profhilo excels at providing deep hydration and skin tightening.

Dr Louise Smyth